Many parents use over-the-counter cough and cold medicines containing the antihistamine Diphenhydramine to help their children alleviate cough and cold symptoms. However a 2006 study found that Diphenhydramine does not affect sleep in infants but that it may actually keep them awake. A similar study also found no improvements in cold and cough symptoms in children who took the above medication.

PEDIATRICS; vol 114 (1); July 2004; pp e85-e90

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