A study of 411 migraine sufferers and an equal number of people with no history of migraine all of whom were evaluated for RLS, headache and depression, found that RLS may be more common in people who suffer from Migraine headaches. Migraine sufferers who also had RLS scored more on a standard screening test for depression. These results suggest an association between RLS and migraines and a co-association with Depression.

Cephalalgia, 2007 Nov; 27 (11):1255-60, Epub 2007 sep21

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