Toronto researchers studied hamsters whose circadian clocks were disrupted by genetic mutation to be out-of–sync with the environment. The researchers found that these animals were more likely than normal hamsters to develop heart & kidney disease, extensive fibrosis and other health problems. Once the Hamsters circadian clocks were normalized these effects were reversed. In accordance, these findings suggest that circadian organization is essential for health and longevity and circadian rhythm disruptions such as sleep deprivation, jet-lag and shift work may lead to heart and kidney disease.
Am J Physiol Regul Integr comp Physiology, 2008 Jul; 2951(1) R369